VPA-induced recurrent pancreatitis in a cystic fibrosis carrier

被引：4

作者：

Dinopoulos, Argirios ^{[1
]}

Karapanou, Olga ^{[1
]}

Alexopoulou, Efi ^{[2
]}

Tzetis, Maria ^{[3
]}

Attilakos, Achileas ^{[1
]}

Fretzayas, Andreas ^{[1
]}

机构：

[1] Univ Athens, Attiko Univ Hosp, Dept Pediat 3, Athens 12462, Haidari, Greece

[2] Univ Athens, Attiko Univ Hosp, Dept Radiol, Athens 12462, Haidari, Greece

[3] Univ Athens, Aghia Sophia Childrens Hosp, Dept Med Genet, Athens 12462, Haidari, Greece

来源：

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2011年 / 15卷 / 05期

关键词：

Valproic acid; Recurrent pancreatitis; Cystic fibrosis; CTFR mutation; GENE;

D O I：

10.1016/j.ejpn.2011.04.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 4.5 years old male with myoclonic epilepsy on Valproic acid (VPA) monotherapy, developed an acute pancreatitis. The discontinuation of VPA and substitution with Levetiracetam was followed by clinical improvement but a relapse of the pancreatitis was noted one month later. The investigation excluded a structural abnormality but revealed a heterozygous CTFR mutation. The contribution of the CTFR mutation on this VPA-induced recurrent pancreatitis cannot be ignored. (C) 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：453 / 455

页数：3

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