Molecular insight into invasive group A streptococcal disease

被引：293

作者：

Cole, Jason N. ^{[1
,2
,3
,4
]}

Barnett, Timothy C. ^{[1
,2
]}

Nizet, Victor ^{[3
,4
,5
]}

Walker, Mark J. ^{[1
,2
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Australian Infect Dis Res Ctr, Brisbane, Qld 4072, Australia

[3] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

[5] Rady Childrens Hosp, San Diego, CA 92123 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 10期

基金：

美国国家卫生研究院;

关键词：

HYALURONIC-ACID CAPSULE; 2-COMPONENT REGULATORY SYSTEM; RHEUMATIC HEART-DISEASE; M-PROTEIN; PLASMINOGEN-BINDING; CYSTEINE PROTEASE; VIRULENCE FACTORS; SORE THROAT; IN-VIVO; PROSPECTIVE SURVEILLANCE;

D O I：

10.1038/nrmicro2648

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Streptococcus pyogenes is also known as group A Streptococcus (GAS) and is an important human pathogen that causes considerable morbidity and mortality worldwide. The GAS serotype M1T1 clone is the most frequently isolated serotype from life-threatening invasive (at a sterile site) infections, such as streptococcal toxic shock-like syndrome and necrotizing fasciitis. Here, we describe the virulence factors and newly discovered molecular events that mediate the in vivo changes from non-invasive GAS serotype M1T1 to the invasive phenotype, and review the invasive-disease trigger for non-M1 GAS. Understanding the molecular basis and mechanism of initiation for streptococcal invasive disease may expedite the discovery of novel therapeutic targets for the treatment and control of severe invasive GAS diseases.

引用

页码：724 / 736

页数：13

共 159 条

[31] Trigger for group A streptococcal M1T1 invasive disease [J].