Phylogenetic and Functional Analysis of Aspergillus fumigatus MGTC, a Fungal Protein Homologous to a Bacterial Virulence Factor

被引：8

作者：

Gastebois, Amandine ^{[1
]}

Potard, Anne-Beatrice Blanc ^{[2
,3
]}

Gribaldo, Simonetta ^{[4
]}

Beau, Remi ^{[1
]}

Latge, Jean Paul ^{[1
]}

Mouyna, Isabelle ^{[1
]}

机构：

[1] Inst Pasteur, Unite Aspergillus, F-75015 Paris, France

[2] Univ Montpellier I, Lab Dynam Interact Membranaires Normales & Pathol, F-34095 Montpellier 05, France

[3] Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier 05, France

[4] Inst Pasteur, Unite Biol Mol Gene Chez Extremophiles, F-75015 Paris, France

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2011年 / 77卷 / 13期

关键词：

HORIZONTAL-GENE-TRANSFER; MULTIPLE SEQUENCE ALIGNMENT; EVOLUTION; SYSTEM; PATHOGENICITY; MAGNESIUM; TRANSPORT; GENOME; MUSCLE;

D O I：

10.1128/AEM.00243-11

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

MgtC is important for the survival of several bacterial pathogens in macrophages and for growth under magnesium limitation. Among eukaryotes, a gene homologous to mgtC was found only in the pathogenic fungus Aspergillus fumigatus. Our data show that the A. fumigatus MgtC (AfuMgtC) protein does not have the same function as the bacterial MgtC proteins.

引用

页码：4700 / 4703

页数：4

共 30 条

[1] MgtC: a key player in intramacrophage survival
Alix, Eric
Blanc-Potard, Anne-Beatric
[J]. TRENDS IN MICROBIOLOGY, 2007, 15 (06) : 252 - 256
[2] Pathogenic molds (including Aspergillus species) in hospital water distribution systems:: a 3-year prospective study and clinical implications for patients with hematologic malignancies
Anaissie, EJ
Stratton, SL
Dignani, MC
Lee, CK
Summerbell, RC
Rex, JH
Monson, TP
Walsh, TJ
[J]. BLOOD, 2003, 101 (07) : 2542 - 2546
[3] Beffa T, 1998, MED MYCOL, V36, P137
[4] MgtC as a horizontally-acquired virulence factor of intracellular bacterial pathogens: Evidence from molecular Phylogeny and comparative genomics
Blanc-Potard, AB
Lafay, B
[J]. JOURNAL OF MOLECULAR EVOLUTION, 2003, 57 (04) : 479 - 486
[5] The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival
BlancPotard, AB
Groisman, EA
[J]. EMBO JOURNAL, 1997, 16 (17) : 5376 - 5385
[6] MUSCLE: multiple sequence alignment with high accuracy and high throughput
Edgar, RC
[J]. NUCLEIC ACIDS RESEARCH, 2004, 32 (05) : 1792 - 1797
[7] The akuBKU80 mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus
Ferreira, MED
Kress, MRVZ
Savoldi, M
Goldman, MHS
Härtl, A
Heinekamp, T
Brakhage, AA
Goldman, GH
[J]. EUKARYOTIC CELL, 2006, 5 (01) : 207 - 211
[8] Evidence of recent interkingdom horizontal gene transfer between bacteria and Candida parapsilosis
Fitzpatrick, David A.
Logue, Mary E.
Butler, Geraldine
[J]. BMC IMMUNOLOGY, 2008, 9 (1)
[9] Horizontal gene transfer of glycosyl hydrolases of the rumen fungi
Garcia-Vallvé, S
Romeu, A
Palau, J
[J]. MOLECULAR BIOLOGY AND EVOLUTION, 2000, 17 (03) : 352 - 361
[10] Horizontal gene transfer promoted evolution of the ability to propagate under anaerobic conditions in yeasts
Gojkovic, Z
Knecht, W
Zameitat, E
Warneboldt, J
Coutelis, JB
Pynyaha, Y
Neuveglise, C
Moller, K
Löffler, M
Piskur, J
[J]. MOLECULAR GENETICS AND GENOMICS, 2004, 271 (04) : 387 - 393

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