Markers for the non-invasive diagnosis of mesothelioma: a systematic review

被引：47
作者：
van der Bij, S. [1 ]
Schaake, E. [2 ]
Koffijberg, H. [1 ]
Burgers, J. A. [2 ]
de Mol, B. A. J. M. [3 ,4 ]
Moons, K. G. M. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands
[2] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Thorac Oncol, NL-1066 CX Amsterdam, Netherlands
[3] Univ Amsterdam, Acad Med Ctr, Dept Cardiothorac Surg, NL-1105 AZ Amsterdam, Netherlands
[4] Eindhoven Univ Technol, Dept Biomed Engn, NL-5600 MB Eindhoven, Netherlands
来源：
BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 08期
关键词：
mesothelioma; diagnosis; biomarkers; cytology; MALIGNANT PLEURAL MESOTHELIOMA; ACCURACY; METAANALYSIS; BIOMARKERS; EFFUSION; FLUID; SERUM; BIAS; OSTEOPONTIN; STATEMENT;
D O I：
10.1038/bjc.2011.104
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: Numerous markers have been evaluated to facilitate the non-invasive diagnostic work-up of mesothelioma. The purpose of this study was to conduct a structured review of the diagnostic performance of non-invasive marker tests for the detection of mesothelioma in patients with suspected mesothelioma. METHODS: Studies on the diagnostic accuracy of serum and cytological markers published till 31 December 2009, available in either PUBMED or Embase, to detect or exclude the presence of mesothelioma were extracted. Study quality was assessed with use of the Quadas criteria. RESULTS: In total, 82 articles were included in this systemic review. Overall, quality of the incorporated studies to address our objective was poor. The most frequently studied immunohistochemical markers for cytological analysis were EMA, Ber-Ep4, CEA, and calretinin. The most frequently investigated serum marker was soluble mesothelin-related protein (SMRP). The markers CEA, Ber-EP4, and calretinin were most valuable in discriminating mesothelioma from other malignant diseases. Markers EMA and SMRP were most valuable in discriminating mesothelioma from non-malignant diseases. No marker performed well in discriminating between mesothelioma and all other diseases. CONCLUSION: Currently, there is only limited evidence to properly assess the value of non-invasive marker tests in the diagnosis of mesothelioma. Studies were of limited value to address our objective and results showed considerable unexplained study heterogeneity. British Journal of Cancer (2011) 104, 1325-1333. doi:10.1038/bjc.2011.104 www.bjcancer.com Published online 29 March 2011 (C) 2011 Cancer Research UK
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页码：1325 / 1333
页数：9
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