Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis

被引：12
作者：
Masutani, M
Nozaki, T
Watanabe, M
Ochiya, T
Hasegawa, F
Nakagawa, H
Suzuki, H
Sugimura, T
机构：
[1] Natl Canc Ctr, Res Inst, Div Biochem, Chuo Ku, Tokyo 1040045, Japan
[2] Mie Univ, Sch Med, Dept Pathol, Tsu, Mie 5148507, Japan
[3] Natl Canc Ctr, Res Inst, Sect Studies Metastasis, Chuo Ku, Tokyo 1040045, Japan
[4] Natl Canc Ctr, Res Inst, Common Lab, Chuo Ku, Tokyo 1040045, Japan
[5] Chugai Pharmaceut Co Ltd, Shizuoka 4120038, Japan
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2001年 / 477卷 / 1-2期
关键词：
poly(ADP-ribosyl)ation; trophoblast giant cells (TGCs); embryonic stem (ES) cells;
D O I：
10.1016/S0027-5107(01)00112-9
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Poly(ADP-ribose) polymerase (Parp) monitors DNA strand breaks and poly(ADP-ribosyl)ates nuclear proteins using NAD as a substrate. The participation of Parp in DNA damage responses has been demonstrated by recent studies using Parp knockout mice. On the other hand, accumulated evidence has shown that Parp is involved in the regulation of gene expression and cell differentiation. In this study, the role of Parp in tumorigenesis and differentiation was studied with Parp(-/-) embryonic stem (ES) cells. When Parp(+/+), Parp(+/-), and Parp(-/-) ES cells were injected subcutaneously into nude mice, teratocarcinoma-like tumors developed from ES cells. However, only tumors derived from Parp(-/-) ES cells showed trophoblast giant cells (TGCs) containing single or multiple megalo-nuclei. These TGCs are located in a large blood-lake like hemorrhage. This example suggests that Parp is not essential for tumor formation, however, it is involved in trophoblastic cell differentiation and could consequently affect tumor phenotype. (C) 2001 Elsevier Science B.V. All rights reserved.
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页码：111 / 117
页数：7
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