Rapid development of dual porous poly(lactic acid) foam using fused deposition modeling (FDM) 3D printing for medical scaffold application

被引：99

作者：

Choi, Won Jun ^{[1
,3
]}

Hwang, Ki Seob ^{[1
]}

Kwon, Hyuk Jun ^{[1
,3
]}

Lee, Chanmin ^{[1
]}

Kim, Chae Hwa ^{[2
]}

Kim, Tae Hee ^{[2
]}

Heo, Seung Won ^{[2
,4
]}

Kim, Jung-Hyun ^{[3
]}

Lee, Jun-Young ^{[1
]}

机构：

[1] Korea Inst Ind Technol KITECH, 89 Yangdaegiro Gil, Cheonan Si 31056, Chungcheongnam, South Korea

[2] Korea Inst Ind Technol KITECH, 143 Hanggaul Ro, Ansan 15588, Gyeonggi Do, South Korea

[3] Yonsei Univ, Dept Chem & Biomol Engn, 50 Yonsei Ro, Seoul 03722, South Korea

[4] Hanyang Univ, Dept Mat Sci & Chem Engn, ERICA Campus,55 Hanyangdaehak Ro, Ansan, Gyeonggi Do, South Korea

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2020年 / 110卷

关键词：

3D printing; Porosity; Extrusion foams; Rheological properties; Cell assay; MECHANICAL-PROPERTIES; PLA; FABRICATION; POLYMER; BONE; EXTRUSION; BIOCOMPATIBILITY; POLYLACTIDE; ELECTROSPUN; FIBROBLAST;

D O I：

10.1016/j.msec.2020.110693

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The poor melt property and brittleness of poly(lactic acid) (PLA) cause difficulties in extrusion foaming and decrease product performance in industrial and research fields. In this paper, the rheological properties of PLA resin were improved using an epoxy chain extension reaction, which led to the improvement of pore properties such as morphology and foamability. Reinforced PLA was extruded in a porous filament, and a scaffold was fabricated with design freedom, one-step processing, and dual porosity by extrusion foaming and 3D printing. In addition, in vitro cell culture tests were performed to verify the cell biology assessment and confirm the potential of the scaffold for application as medical scaffolds.

引用

页数：9

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