MRI Interscanner Agreement of the Association between the Susceptibility Vessel Sign and Histologic Composition of Thrombi

被引：23

作者：

Bourcier, Romain ^{[1
]}

Detraz, Lili ^{[1
]}

Serfaty, Jean Michel ^{[3
,4
]}

Delasalle, Beatrice Guyomarch ^{[5
]}

Mirza, Mahmood ^{[6
]}

Derraz, Imad ^{[2
]}

Toulgoat, Frederique ^{[7
]}

Naggara, Olivier ^{[8
,9
]}

Toquet, Claire ^{[10
]}

Desal, Hubert ^{[1
]}

机构：

[1] Hop Rene & Guillaume Laennec, CHU Nantes, Dept Neuroradiol, St Herblain, France

[2] CHU Nancy, Dept Neuroradiol, Nancy, France

[3] Hop Rene & Guillaume Laennec, CHU Nantes, Imagerie Cardiaque & Vasc, Nantes, France

[4] Inst Thorax, INSERM, UMR 1087, Paris, France

[5] Univ Nantes, CNRS, CHU Nantes, Hop Rene & Guillaume Laennec,Inst Thorax,INSERM, Nantes, France

[6] NTI, Nantes, France

[7] Hop Hotel Dieu, CHU Nantes, Cent Dept Radiol & Med Imaging, Nantes, France

[8] Ctr Hosp St Anne, Dept Neuroradiol, Paris, France

[9] Univ Paris 05, INSERM, U894, Paris, France

[10] Hop Hotel Dieu, CHU Nantes, Dept Pathol, Nantes, France

来源：

JOURNAL OF NEUROIMAGING | 2017年 / 27卷 / 06期

关键词：

Stroke; SVS; MRI interscanner agreement; T2*sequence; ACUTE ISCHEMIC-STROKE; EARLY RECANALIZATION; GRADIENT-ECHO; ENDOVASCULAR TREATMENT; HOUR; THROMBECTOMY; THROMBOLYSIS; METAANALYSIS; PREDICTORS; SEQUENCES;

D O I：

10.1111/jon.12464

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BACKGROUND AND PURPOSEThe susceptibility vessel sign (SVS) on magnetic resonance imaging (MRI) is related to thrombus location, composition, and size in acute stroke. No previous study has determined its inter-MRI scanner variability. We aimed to compare the diagnostic accuracy in-vitro of four different MRI scanners for the characterization of histologic thrombus composition. METHODSThirty-five manufactured thrombi analogs of different composition that were histologically categorized as fibrin-dominant, mixed, or red blood cell (RBC)-dominant were scanned on four different MRI units with T2* sequence. Nine radiologists, blinded to thrombus composition and MRI scanner model, classified twice, in a 2-week interval, the SVS of each thrombus as absent, questionable, or present. We calculated the weighted kappa with 95% confidence interval (CI), sensitivity, specificity and accuracy of the SVS on each MRI scanner to detect RBC-dominant thrombi. RESULTSThe SVS was present in 42%, absent in 33%, and questionable in 25% of thrombi. The interscanner agreement was moderate to good, ranging from .45 (CI: .37-.52) to .67 (CI: .61-.74). The correlation between the SVS and the thrombus composition was moderate (: .50 [CI: .44-.55]) to good : .76 ([CI: .72-.80]). Sensitivity, specificity, and accuracy to identify RBC-dominant clots were significantly different between MRI scanners (P < .001). CONCLUSIONThe diagnostic accuracy of SVS to determine thrombus composition varies significantly among MRI scanners. Normalization of T2*sequences between scanners may be needed to better predict thrombus composition in multicenter studies.

引用

页码：577 / 582

页数：6

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