The Fork in the Road: Histone Partitioning During DNA Replication

被引:42
作者
Annunziato, Anthony T. [1 ]
机构
[1] Boston Coll, Dept Biol, Chestnut Hill, MA 02467 USA
关键词
chromatin; nucleosome; tetramer; histone; acetylation; methylation; replication; splitting; epigenetics; INACTIVE X-CHROMOSOME; CHROMATIN REPLICATION; CHAPERONE ASF1; CONSERVATIVE SEGREGATION; PARENTAL NUCLEOSOMES; NASCENT CHROMATIN; ACTIVE CHROMATIN; STRUCTURAL BASIS; H3-H4; TETRAMERS; CORE HISTONES;
D O I
10.3390/genes6020353
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
In the following discussion the distribution of histones at the replication fork is examined, with specific attention paid to the question of H3/H4 tetramer "splitting." After a presentation of early experiments surrounding this topic, more recent contributions are detailed. The implications of these findings with respect to the transmission of histone modifications and epigenetic models are also addressed.
引用
收藏
页码:353 / 371
页数:19
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