The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

被引：1323

作者：

Caly, Leon ^{[1
]}

Druce, Julian D. ^{[1
]}

Catton, Mike G. ^{[1
]}

Jans, David A. ^{[2
]}

Wagstaff, Kylie M. ^{[2
]}

机构：

[1] Royal Melbourne Hosp, Peter Doherty Inst Infect & Immun, Victorian Infect Dis Reference Lab, Melbourne, Vic 3000, Australia

[2] Monash Univ, Biomed Discovery Inst, Clayton, Vic 3800, Australia

来源：

ANTIVIRAL RESEARCH | 2020年 / 178卷

基金：

英国医学研究理事会;

关键词：

NUCLEAR IMPORT; NUCLEOCAPSID PROTEIN; LOCALIZATION; VIRUSES; TRANSPORT; SAFETY;

D O I：

10.1016/j.antiviral.2020.104787

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 h post infection with SARS-CoV-2 able to effect -5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrants further investigation for possible benefits in humans.

引用

页数：4

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