Short-step synthesis of tamoxifen and its derivatives via the three-component coupling reaction and migration of the double bond

被引：24

作者：

Shiina, I ^{[1
]}

Suzuki, M ^{[1
]}

Yokoyama, K ^{[1
]}

机构：

[1] Sci Univ Tokyo, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 1628601, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 05期

关键词：

D O I：

10.1016/j.tetlet.2003.11.119

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The anti-tumor agent, tamoxifen, is easily synthesized by the successive allylation of benzaldehyde and the Friedel-Crafts alkylation reaction of anisole with the intermediary homoallyl silyl ethers, followed by the migration of the double bond to form the desired tetra-substituted ethylenes. Several derivatives of tamoxifen are also produced according to a similar synthetic strategy. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：965 / 967

页数：3

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