Genetic analysis of IREB2, FAM13A and XRCC5 variants in Chinese Han patients with chronic obstructive pulmonary disease

被引：28
作者：
Guo, Yi [1 ,2 ,3 ]
Lin, Hua [4 ]
Gao, Kai [2 ]
Xu, Hongbo [2 ]
Deng, Xiong [2 ]
Zhang, Qiang [4 ]
Luo, Zigiang [1 ]
Sun, Shenghua [4 ]
Deng, Hao [2 ,4 ]
机构：
[1] Cent S Univ, Dept Physiol, Xiangya Med Sch, Changsha 410013, Hunan, Peoples R China
[2] Cent S Univ, Xiangya Hosp 3, Ctr Med Expt, Changsha 410013, Hunan, Peoples R China
[3] Cent S Univ, Dept Med Informat, Xiangya Med Sch, Changsha 410013, Hunan, Peoples R China
[4] Cent S Univ, Xiangya Hosp 3, Dept Resp Med, Changsha 410013, Hunan, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 415卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Chronic obstructive pulmonary disease; Genetics; IREB2; FAM13A; XRCC5; Association;
D O I：
10.1016/j.bbrc.2011.10.042
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recently, variants (rs2568494, rs2869967 and rs3821104) in the IREB2, FAM13A and XRCC5 genes were found to be associated with chronic obstructive pulmonary disease (COPD) in non-Asian populations by genome-wide association study (GWAS) analysis, To evaluate whether variants in these genes are related to COPD in Chinese Han population, we investigated COPD patients of Chinese Han ethnicity from Mainland China. Significant differences in genotypic distributions (chi(2)= 6.319, p = 0.042 for rs2869967; chi(2) = 6.062, p = 0.048 for rs3821104) and allele distributions (chi(2) = 4.014, p = 0.045 for rs2869967; chi(2) = 5.607, p = 0.018 for rs3821104) were observed between patients and control subjects for variants rs2869967 and rs3821104, whereas no statistically significant associations for genotypic and allelic distribution between IREB2 rs2568494 and COPD phenotype (p > 0.05) were identified. Our results support that FAM13A rs2869967 and XRCC5 rs3821104 are associated with COPD in Chinese Han population. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：284 / 287
页数：4
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