The Emerging Role of Rab GTPases in the Pathogenesis of Parkinson's Disease

被引：49
作者：
Gao, Yujing [1 ,2 ]
Wilson, Gabrielle R. [1 ,2 ]
Stephenson, Sarah E. M. [1 ,2 ]
Bozaoglu, Kiymet [1 ,2 ]
Farrer, Matthew J. [3 ]
Lockhart, Paul J. [1 ,2 ]
机构：
[1] Murdoch Childrens Res Inst, Bruce Lefroy Ctr Genet Hlth Res, Melbourne, Vic, Australia
[2] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia
[3] Univ British Columbia, Ctr Appl Neurogenet, Djavad Mowafaghian Ctr Brain Hlth, Dept Med Genet, Vancouver, BC, Canada
来源：
MOVEMENT DISORDERS | 2018年 / 33卷 / 02期
基金：
英国医学研究理事会;
关键词：
RAB GTPase; Parkinson's disease; alpha-synuclein; LRRK2; VPS35; ALPHA-SYNUCLEIN INTERACTIONS; GENE-MUTATIONS; INTELLECTUAL DISABILITY; COGNITIVE IMPAIRMENT; SYNAPTIC DYSFUNCTION; RECEPTOR TRAFFICKING; RETROMER COMPLEX; NEURON LOSS; PROTEIN; VPS35;
D O I：
10.1002/mds.27270
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The identification of pathogenic mutations in Ras analog in brain 39B (RAB39B) and Ras analog in brain 32 (RAB32) that cause Parkinson's disease (PD) has highlighted the emerging role of protein trafficking in disease pathogenesis. Ras analog in brain (Rab) Guanosine triphosphatase (GTPase) function as master regulators of membrane trafficking, including vesicle formation, movement along cytoskeletal networks, and membrane fusion. Recent studies have linked Rab GTPases with alpha-synuclein, Leucine-rich repeat kinase 2, and Vacuolar protein sorting 35, 3 key proteins in PD pathogenesis. In this review, we discuss the various RAB GTPases associated with PD, current progress in the research, and potential future directions. Investigations into the function of RAB GTPases will likely provide significant insight into the etiology of PD and identify novel therapeutic targets for a currently incurable disease. (c) 2018 International Parkinson and Movement Disorder Society
引用
收藏
页码：196 / 207
页数：12
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