Mg-promoted regio- and stereoselective C-acylation of aromatic α,β-unsaturated carbonyl compounds

被引：47
|
作者：
Ohno, T
Sakai, M
Ishino, Y
Shibata, T
Maekawa, H
Nishiguchi, I
机构：
[1] Nagaoka Univ Technol, Dept Chem, Nagaoka, Niigata 9402188, Japan
[2] Osaka Municipal Tech Res Inst, Joto Ku, Osaka 5368553, Japan
来源：
ORGANIC LETTERS | 2001年 / 3卷 / 22期
关键词：
D O I：
10.1021/ol016376e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Treatment of aromatic alpha,beta -unsaturated carbonyl compounds with Mg turnings in the presence of acid anhydrides/TMSCI or acyl chlorides in DMF brought about a facile and efficient cross-coupling to give C-acylation products, which are useful 1,4-dicarbonyl compounds, in good to excellent yields in a regio- and stereoselective manner. The reaction may be initiated by electron transfer from magnesium to the substrates.
引用
收藏
页码：3439 / 3442
页数：4
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