An overview of molecular mechanisms in cadmium toxicity

被引：122

作者：

Dukic-Cosic, Danijela ^{[1
]}

Baralic, Katarina ^{[1
]}

Javorac, Dragana ^{[1
]}

Djordjevic, Aleksra Buha ^{[1
]}

Bulat, Zorica ^{[1
]}

机构：

[1] Univ Belgrade, Fac Pharm, Dept Toxicol Akad Danilo Soldatovic, Vojvode Stepe 450, Belgrade 11221, Serbia

来源：

CURRENT OPINION IN TOXICOLOGY | 2020年 / 19卷

关键词：

Cadmium; Gene relation; Apoptosis; Autophagy; Oxidative stress; Bioelements; OXIDATIVE STRESS; DNA-REPAIR; CELLULAR MECHANISMS; INDUCED APOPTOSIS; EPITHELIAL-CELLS; ZINC; MAGNESIUM; KIDNEY; LIVER; INVOLVEMENT;

D O I：

10.1016/j.cotox.2019.12.002

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Cadmium (Cd), one of the most important environmental pollutants, can cause a number of toxic effects. These effects are the result of more than one mechanisms of toxicity, all interrelated in their complexity. Thus, it is difficult to identify a fine line between these mechanisms of Cd toxicity, making their understanding highly complicated. The most important mechanisms by which Cd manifests its toxic effects include changes in gene expression and inhibition of damaged DNA repair, interference of apoptosis and autophagy, oxidative stress, and interaction with bioelements. In this review, we will give a brief overview of the recent developments and findings on the most relevant general and specific mechanisms and molecular pathways of Cd toxicity.

引用

页码：56 / 62

页数：7

共 67 条

[1] Rutin, an antioxidant flavonoid, induces glutathione and glutathione peroxidase activities to protect against ethanol effects in cadmium-induced oxidative stress in the testis of adult rats [J].