Functional consequences of toll-like receptor 4 polymorphisms

被引：209

作者：

Ferwerda, Bart ^{[1
,2
]}

McCall, Matthew B. B. ^{[1
,3
]}

Verheijen, Karlijn ^{[1
,2
]}

Kullberg, Bart-Jan ^{[1
,2
]}

van der Ven, Andre J. A. M. ^{[1
,2
]}

Van der Meer, Jos W. M. ^{[1
,2
]}

Netea, Mihai G. ^{[1
,2
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Med 463, Dept Internal Med, NL-6500 HB Nijmegen, Netherlands

[2] Univ Nijmegen, Ctr Infect Dis, Nijmegen, Netherlands

[3] Univ Nijmegen, Dept Parasitol, Nijmegen, Netherlands

来源：

MOLECULAR MEDICINE | 2008年 / 14卷 / 5-6期

关键词：

D O I：

10.2119/2007-00135.Ferwerda

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toll-like receptor 4 (TLR4) is an important pathogen recognition receptor that recognizes mainly lipopolysaccharide (LPS) of Gram-negative bacteria, but also structures from fungal and mycobacterial pathogens, as well as endogenous ligands. Two nonsynonymous polymorphisms of TLR4, Asp299Gly and Thr399IIe, have been suggested to alter the function of the receptor. Some, but not all, studies have proposed that these polymorphisms lead to reduced cytokine response and increased susceptibility to Gram-negative infections. In this review, we compare studies that assessed the effect of the Asp299Gly and Thr399IIe polymorphisms on susceptibility to Gram-negative infections and examine the phenotypic consequences of these polymorphisms. In addition, we review the geographical distribution of TLR4 polymorphisms and present a model for evolutionary pressures on the TLR4 genetic make-up.

引用

页码：346 / 352

页数：7

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