Nanomaterials for delivery of nucleic acid to the central nervous system (CNS)

被引：29
|
作者：
Wang, Danyang [1 ]
Wu, Lin-Ping [1 ,2 ]
机构：
[1] Univ Copenhagen, Dept Pharm, Fac Hlth & Med Sci, Univ Pk 2, DK-2100 Copenhagen, Denmark
[2] Guangzhou RiboBio Co Ltd, Guangzhou 510663, Guangdong, Peoples R China
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 70卷
关键词：
Nanomaterials; Nucleic acid; Blood brain barriers; Gene therapy; RNA interference; Drug delivery; Central nervous system; BLOOD-BRAIN-BARRIER; CELL-PENETRATING PEPTIDES; DRUG-DELIVERY; GENE DELIVERY; NANOGEL FORMULATIONS; CATIONIC COPOLYMERS; P-GLYCOPROTEIN; NANOPARTICLES; SIRNA; MECHANISM;
D O I：
10.1016/j.msec.2016.04.011
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Billions of dollars have been invested in the therapeutic application of nucleic acid-based agents in humans in recent years. There are inspirable data from ongoing clinical trial for different diseases. However, in order to widely apply nucleic acid in prevention, diagnosis and treatment of age-related disease, such as neurodegeneration and disorders, suitable, safe and effective drug delivery nanocarriers have to been developed to overcome the blood brain barrier (BBB), which is the most inflexible barrier in human body. Here, we highlight the structure and function of barriers in the central nervous system (CNS) and summary several types of nanomaterials which can be potentially used in the brain delivery nucleic acid. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：1039 / 1046
页数：8
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