Nanomaterials for delivery of nucleic acid to the central nervous system (CNS)

被引：31
作者：
Wang, Danyang [1 ]
Wu, Lin-Ping [1 ,2 ]
机构：
[1] Univ Copenhagen, Dept Pharm, Fac Hlth & Med Sci, Univ Pk 2, DK-2100 Copenhagen, Denmark
[2] Guangzhou RiboBio Co Ltd, Guangzhou 510663, Guangdong, Peoples R China
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 70卷
关键词：
Nanomaterials; Nucleic acid; Blood brain barriers; Gene therapy; RNA interference; Drug delivery; Central nervous system; BLOOD-BRAIN-BARRIER; CELL-PENETRATING PEPTIDES; DRUG-DELIVERY; GENE DELIVERY; NANOGEL FORMULATIONS; CATIONIC COPOLYMERS; P-GLYCOPROTEIN; NANOPARTICLES; SIRNA; MECHANISM;
D O I：
10.1016/j.msec.2016.04.011
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Billions of dollars have been invested in the therapeutic application of nucleic acid-based agents in humans in recent years. There are inspirable data from ongoing clinical trial for different diseases. However, in order to widely apply nucleic acid in prevention, diagnosis and treatment of age-related disease, such as neurodegeneration and disorders, suitable, safe and effective drug delivery nanocarriers have to been developed to overcome the blood brain barrier (BBB), which is the most inflexible barrier in human body. Here, we highlight the structure and function of barriers in the central nervous system (CNS) and summary several types of nanomaterials which can be potentially used in the brain delivery nucleic acid. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：1039 / 1046
页数：8
相关论文
共 115 条
[1]   Structure and function of the blood-brain barrier [J].
Abbott, N. Joan ;
Patabendige, Adjanie A. K. ;
Dolman, Diana E. M. ;
Yusof, Siti R. ;
Begley, David J. .
NEUROBIOLOGY OF DISEASE, 2010, 37 (01) :13-25
[2]   Astrocyte-endothelial interactions at the blood-brain barrier [J].
Abbott, NJ ;
Rönnbäck, L ;
Hansson, E .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (01) :41-53
[3]   Transporting therapeutics across the blood-brain barrier [J].
Abbott, NJ ;
Romero, IA .
MOLECULAR MEDICINE TODAY, 1996, 2 (03) :106-113
[4]   Biological targeting and innovative therapeutic interventions with phage-displayed peptides and structured nucleic acids (aptamers) [J].
Ahmadvand, Davoud ;
Rahbarizadeh, Fatemeh ;
Moghimi, Seyed Moein .
CURRENT OPINION IN BIOTECHNOLOGY, 2011, 22 (06) :832-838
[5]   Molecular basis for target RNA recognition and cleavage by human RISC [J].
Ameres, Stefan Ludwig ;
Martinez, Javier ;
Schroeder, Renee .
CELL, 2007, 130 (01) :101-112
[6]   Delivery of therapeutic agents to the central nervous system: the problems and the possibilities [J].
Begley, DJ .
PHARMACOLOGY & THERAPEUTICS, 2004, 104 (01) :29-45
[7]   The blood-brain barrier: Principles for targeting peptides and drugs to the central nervous system [J].
Begley, DJ .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1996, 48 (02) :136-146
[8]   Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging [J].
Bhaskar, Sonu ;
Tian, Furong ;
Stoeger, Tobias ;
Kreyling, Wolfgang ;
de la Fuente, Jesus M. ;
Grazu, Valeria ;
Borm, Paul ;
Estrada, Giovani ;
Ntziachristos, Vasilis ;
Razansky, Daniel .
PARTICLE AND FIBRE TOXICOLOGY, 2010, 7
[9]   Glucose, insulin and the brain: modulation of cognition and synaptic plasticity in health and disease: a preface [J].
Biessels, GJ ;
Bravenboer, B ;
Gispen, WH .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 490 (1-3) :1-4
[10]   RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise? [J].
Bobbin, Maggie L. ;
Rossi, John J. .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56, 2016, 56 :103-122
12345678910