SSRIs and conditioned fear

被引：40

作者：

Inoue, Takeshi ^{[1
]}

Kitaichi, Yuji ^{[1
]}

Koyama, Tsukasa ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Psychiat, Kita Ku, Sapporo, Hokkaido 0608638, Japan

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2011年 / 35卷 / 08期

关键词：

Amygdala; Conditioned freezing; Contextual conditioned fear; Hippocampus; Selective serotonin reuptake inhibitor; Serotonin (5-HT); SEROTONIN REUPTAKE INHIBITOR; INDUCED FREEZING BEHAVIOR; RAT PREFRONTAL CORTEX; POTENTIATED STARTLE; FRONTAL-CORTEX; INESCAPABLE FOOTSHOCKS; RECEPTOR ANTAGONISTS; ANIMAL-MODELS; IN-VIVO; C-FOS;

D O I：

10.1016/j.pnpbp.2011.09.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Among drugs that act on serotonergic neurotransmission, selective serotonin (5-HT) reuptake inhibitors (SSRIs) are now the gold standard for the treatment of anxiety disorders. The precise mechanisms of the anxiolytic actions of SSRIs are unclear. We reviewed the literature related to the effects of SSRIs and the neurochemical changes of 5-HT in conditioned fear. Acute SSRIs and 5-HT1A receptor agonists reduced the acquisition and expression of contextual conditioned fear. Chronic SSRI administration enhanced anxiolytic-like effects. Microinjection studies revealed the amygdala as the target brain region of both classes of serotonergic drugs, and the hippocampus as the target of 5-HT1A receptor agonists. These findings highlight the contribution of post-synaptic 5-HT receptors, especially 5-HT1A receptors, to the anxiolytic-like effects of serotonergic drugs. These results support the new 5-HT hypothesis of fear/anxiety: the facilitation of 5-HT neurotransmission ameliorates fear/anxiety. Furthermore, these behavioral data provide a new explanation of neurochemical adaptations to contextual conditioned fear: increased 5-HT transmission seems to decrease, not increase, fear. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1810 / 1819

页数：10

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