Rotavirus vaccines: current global impact and future perspectives

被引:23
作者
Burnett, Eleanor [1 ]
Yen, Catherine [1 ]
Tate, Jacqueline E. [1 ]
Parashar, Umesh D. [1 ]
机构
[1] Ctr Dis Control & Prevent, Div Viral Dis, 1600 Clifton Rd NE, Atlanta, GA 30329 USA
关键词
rotavirus; rotavirus vaccine; vaccines prophylactic; CONTROLLED CASE-SERIES; INTUSSUSCEPTION RISK; UNITED-STATES; GASTROENTERITIS HOSPITALIZATIONS; DIARRHEAL HOSPITALIZATIONS; DOUBLE-BLIND; VACCINATION; CHILDREN; MONOVALENT; IMMUNOGENICITY;
D O I
10.2217/fvl-2016-0082
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
As of May 2016, 81 countries have introduced Rotarix or RotaTeq rotavirus vaccines into their national immunization program. Despite initially slow uptake in some countries and differences in vaccine effectiveness (VE) between high-, low- and middle-income countries, impact of the vaccines has been swift and striking in all settings, with good VE against vaccine-type and nonvaccine-type strains. Newly published research indicates poor nutrition is associated with decreased VE and breastfeeding at the time of vaccination does not affect vaccine response. Vaccines in development and proposed alternate schedules also promise to address limitations of the current vaccines and optimize rotavirus disease prevention.
引用
收藏
页码:699 / 708
页数:10
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