Pharmacotherapy for postural tachycardia syndrome

被引:49
作者
Miller, Amanda J. [1 ]
Raj, Satish R. [2 ,3 ]
机构
[1] Penn State Coll Med, Dept Neural & Behav Sci, 500 Univ Dr,Mail Code H109, Hershey, PA USA
[2] Vanderbilt Univ, Med Ctr, Auton Dysfunct Ctr, Div Clin Pharmacol, Nashville, TN USA
[3] Univ Calgary, Libin Cardiovasc Inst Alberta, Dept Cardiac Sci, GAC70 HRIC Bldg,3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada
来源
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2018年 / 215卷
基金
美国国家卫生研究院; 加拿大健康研究院;
关键词
Postural tachycardia syndrome; Postural orthostatic tachycardia syndrome; Orthostatic intolerance; Tachycardia; Autonomic nervous system diseases; Therapeutics; INAPPROPRIATE SINUS TACHYCARDIA; NEUROGENIC ORTHOSTATIC HYPOTENSION; CHRONIC-FATIGUE-SYNDROME; DOUBLE-BLIND; DECREASES TACHYCARDIA; SLEEP DISTURBANCES; EXERCISE CAPACITY; IMPROVES SYMPTOMS; INTOLERANCE; IVABRADINE;
D O I
10.1016/j.autneu.2018.04.008
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Postural tachycardia syndrome (POTS) is a disorder characterized by the presence of orthostatic symptoms (including lightheadedness, palpitations, nausea, dyspnea, and tremulousness) as well as excessive upright tachycardia. POTS predominantly affects women of childbearing age. Treating POTS involves a multi-faceted approach using non-pharmacological and pharmacological interventions. There are no pharmacological treatments that are currently United States Food and Drug Administration (FDA) approved for POTS due to lack of randomized controlled trials. Yet, several medications can improve POTS symptoms and are supported by small prospective studies or retrospective case series. Drugs that are most commonly used for POTS target the following mechanisms 1) blood volume expansion, 2) reduction of heart rate, 3) peripheral vasoconstriction and 4) sympatholysis. Pharmacological approaches can also be used to target specific symptoms including "brain fog," fatigue, sleep, and depression. This review outlines pharmacological approaches for treating POTS and summarizes evidence supporting each treatment approach.
引用
收藏
页码:28 / 36
页数:9
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