Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

被引：115

作者：

Periyasami, Govindasami ^{[1
]}

Raghunathan, Raghavachary ^{[1
]}

Surendiran, Gangadharan ^{[2
]}

Mathivanan, Narayanasamy ^{[2
]}

机构：

[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India

[2] Univ Madras, Ctr Adv Studies Bot, Madras 600025, Tamil Nadu, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 07期

关键词：

1,3-dipolar cycloaddition; azomethine ylide; microwave; pyrrolizidine;

D O I：

10.1016/j.bmcl.2008.02.065

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel dispirooxindolopyrrolizidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from proline and isatin with the dipolarophile (E)-2-arylidine-1-keto carbazoles. The synthesized cycloadducts were evaluated for antimicrobial activities. Compounds 7d and 7e showed relatively good antibacterial and antifungal activities. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2342 / 2345

页数：4

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