Biotechnological potential and applications of microbial consortia

被引：140

作者：

Qian, Xiujuan ^{[1
]}

Chen, Lin ^{[1
]}

Sui, Yuan ^{[2
]}

Chen, Chong ^{[2
]}

Zhang, Wenming ^{[1
,3
]}

Zhou, Jie ^{[1
,3
]}

Dong, Weiliang ^{[1
,3
]}

Jiang, Min ^{[1
,3
]}

Xin, Fengxue ^{[1
,3
]}

Ochsenreither, Katrin ^{[4
]}

机构：

[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Puzhu South Rd 30, Nanjing 211800, Jiangsu, Peoples R China

[2] Nanjing Tech Univ, Coll 2011, Nanjing, Peoples R China

[3] Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing, Peoples R China

[4] Karlsruhe Inst Technol, Inst Proc Engn Life Sci, Sect Tech Biol 2, Fritz Haber Weg 4, D-76131 Karlsruhe, Germany

来源：

BIOTECHNOLOGY ADVANCES | 2020年 / 40卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Microbial consortia application; Human health supervision; Valuable compounds synthesis; Consolidated bioprocessing; Environment bio-remediation; Microbial consortia construction challenges; ESCHERICHIA-COLI COCULTURE; BACTERIAL CONSORTIUM; ETHANOL-PRODUCTION; WASTE-WATER; MIXED-CULTURE; SACCHAROMYCES-CEREVISIAE; ASPERGILLUS-FUMIGATUS; CHEMICAL DIVERSITY; CELL COMMUNICATION; ACID BIOSYNTHESIS;

D O I：

10.1016/j.biotechadv.2019.107500

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent advances in microbial consortia present a valuable approach for expanding the scope of metabolic engineering. Systems biology enable thorough understanding of diverse physiological processes of cells and their interactions, which in turn offers insights into the optimal design of synthetic microbial consortia. Yet, the study of synthetic microbial consortia is still in early infancy, facing many unknowns and challenges in intercellular communication and construction of stable and controllable microbial consortia systems. In this review, we comprehensively discussed the recent application of defined microbial consortia in the fields of human health monitoring and medicine exploitation, valuable compounds synthesis, consolidated bioprocessing of lignocellulosic materials and environmental bioremediation. Moreover, the outstanding challenges and future directions to advance the development of high-efficient, stable and controllable synthetic microbial consortia were highlighted.

引用

页数：13

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