Should chloroquine be laid to rest?

被引：39

作者：

Ginsburg, H ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Life Sci, Dept Biol Chem, IL-91904 Jerusalem, Israel

来源：

ACTA TROPICA | 2005年 / 96卷 / 01期

关键词：

malaria; Plasmodium falciparum; chloroquine; drug resistance; chemosensitization;

D O I：

10.1016/j.actatropica.2005.06.021

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Chloroquine (CQ) has been the front line antimalarial drug due to its efficacy, low cost and scanty side effects, until resistance has evolved. Although its use has been officially discontinued in most malaria-affected countries, it is still widely used. Practical and pharmacological considerations indicate that it could be still used in semi-immune adults and that more efficient treatment protocols could be devised to treat even patients infected with CQ-resistant parasite strains. Since its antimalarial activity is pleiotropic, drug resistance may be due to different mechanisms, each amenable to reversal by drug combination. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：16 / 23

页数：8

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