Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity

被引：9

作者：

Lewandowski, Dawid ^{[1
]}

Lewandowska, Marta ^{[1
]}

Ruszkowski, Piotr ^{[2
]}

Pinska, Anita ^{[2
]}

Schroeder, Grzegorz ^{[1
]}

机构：

[1] Adam Mickiewicz Univ, Fac Chem, PL-60780 Poznan, Poland

[2] Poznan Univ Med Sci, Fac Pharm, Poznan, Poland

来源：

PLOS ONE | 2015年 / 10卷 / 05期

关键词：

IN-VITRO; SURFACE FUNCTIONALIZATION; NUCLEOSIDE ANALOGS; CONTROLLED-RELEASE; PH; 5-FLUOROURACIL; NANOPARTICLES; ADSORPTION; AGENTS; VIVO;

D O I：

10.1371/journal.pone.0126251

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Novel zidovudine derivatives, able to be covalently conjugated to silica surface, have been obtained and grafted to SBA-15 mesoporous silica. Cytotoxic activity of the hybrid organic-inorganic (zidovudine derivatives-silica) systems against HeLa and KB cell lines has been analyzed. Addition of folic acid had a positive influence on the cytotoxicity. Up to 69% of HeLa and 65% of KB tumor cells growth inhibition has been achieved at low silica concentration used (10 mu g/mL).

引用

页数：12

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