Homogeneous Pd-catalyzed enantioselective decarboxylative protonation

被引：69

作者：

Marinescu, Smaranda C. ^{[1
]}

Nishimata, Toyoki ^{[1
]}

Mohr, Justin T. ^{[1
]}

Stoltz, Brian M. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 06期

关键词：

D O I：

10.1021/ol702821j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tertiary carbon stereocenters at the alpha-position are reported. The highly reactive catalyst tolerates a variety of substrate substitution and-functionality, and generates enantioenriched cyclic ketones from racemic allyl beta-ketoester starting materials.

引用

页码：1039 / 1042

页数：4

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