Receptors for gamma-interferon encoded by poxviruses: Implications for the unknown origin of vaccinia virus

被引：31

作者：

Alcami, A ^{[1
]}

Smith, GL ^{[1
]}

机构：

[1] UNIV OXFORD,SIR WILLIAM DUNN SCH PATHOL,OXFORD OX1 3RE,ENGLAND

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 08期

关键词：

D O I：

10.1016/0966-842X(96)10051-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poxviruses encode soluble interferon-gamma receptors (IFN-gamma Rs) that inhibit IFN-gamma activity and play a major role in virus pathogenesis. In contrast to the highly species specific cellular homologues, the vaccinia IFN-gamma R has novel broad species specificity. This has implications for the unknown origin and natural host(s) of vaccinia virus, the vaccine used for smallpox eradication.

引用

页码：321 / 326

页数：6

共 38 条

[1] NUCLEOTIDE-SEQUENCE OF 21.8 KBP OF VARIOLA MAJOR VIRUS-STRAIN HARVEY AND COMPARISON WITH VACCINIA VIRUS [J].

AGUADO, B ;

SELMES, IP ;

SMITH, GL .

JOURNAL OF GENERAL VIROLOGY, 1992, 73 :2887-2902

[2] CYTOKINE RECEPTORS ENCODED BY POXVIRUSES - A LESSON IN CYTOKINE BIOLOGY [J].

ALCAMI, A ;

SMITH, GL .

IMMUNOLOGY TODAY, 1995, 16 (10) :474-478

[3]

ALCAMI A, 1995, J VIROL, V69, P4633

[4]

Baxby D., 1981, Jenner's Smallpox Vaccine: The Riddle of Vaccinia Virus and its Origin

[5] POXVIRUS PATHOGENESIS [J].

BULLER, RML ;

PALUMBO, GJ .

MICROBIOLOGICAL REVIEWS, 1991, 55 (01) :80-122

[6] VACCINIA VIRUS B18R GENE ENCODES A TYPE-I INTERFERON-BINDING PROTEIN THAT BLOCKS INTERFERON-ALPHA TRANSMEMBRANE SIGNALING [J].

COLAMONICI, OR ;

DOMANSKI, P ;

SWEITZER, SM ;

LARNER, A ;

BULLER, RML .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (27) :15974-15978

[7] A study of the lesions produced experimentally by cowpox virus. [J].

Downie, AW .

JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1939, 48 (02) :361-379

[8] THE MOLECULAR CELL BIOLOGY OF INTERFERON-GAMMA AND ITS RECEPTOR [J].

FARRAR, MA ;

SCHREIBER, RD .

ANNUAL REVIEW OF IMMUNOLOGY, 1993, 11 :571-611

[9]

Fenner F., 1989, MONKEYPOX VIRUS ORTH, P1

[10] PURIFICATION AND BIOCHEMICAL-CHARACTERIZATION OF A SOLUBLE MOUSE INTERFERON-GAMMA RECEPTOR PRODUCED IN INSECT CELLS [J].

FOUNTOULAKIS, M ;

SCHLAEGER, EJ ;

GENTZ, R ;

JURANVILLE, JF ;

MANNEBERG, M ;

OZMEN, L ;

GAROTTA, G .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 198 (02) :441-450

← 1 2 3 4 →