Buyuan Congnao decoction decreases hippocampal beta-amyloid expression in a rat model of Alzheimer's disease

被引：4

作者：

Chen, Min ^{[1
]}

Wang, Jing ^{[1
]}

Ming, Cairong ^{[2
]}

机构：

[1] Liaoning Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Geriatr, Shenyang 110032, Liaoning Provin, Peoples R China

[2] Liaoning Univ Tradit Chinese Med, Expt Ctr, Dept Morphol Lab, Shenyang 110032, Liaoning Provin, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 09期

关键词：

Alzheimer's disease; Buyuan Congnao decoction; beta-amyloid; immunofluorescence; Morris water maze; neural regeneration; A-BETA; COGNITIVE DEFICITS; APP;

D O I：

10.3969/j.issn.1673-5374.2012.09.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A mixture of ibotenic acid and beta-amyloid 1-42 was injected into the hippocampus of a rat model of Alzheimer's disease, followed by intragastric administration of a traditional Chinese medicine Buyuan Congnao decoction (main components included radix astragati, radix polygoni multiflori preparata, rhizoma acod talarinowii, radix polygalae, fructus alpiniae oxyphyllae, and radix glycyrrhizae preparata) and a piracetam suspension. Following treatment with traditional Chinese medicine or western medicine, beta-amyloid expression decreased and neuronal morphology was normal in the rat hippocampal CA1 region, in addition to significantly shortened average latency in the Morris water navigation task. These findings suggested that compound prescription of Buyuan Congnao decoction, similar to the curative effects of piracetam, decreased hippocampal beta-amyloid expression in a rat model of Alzheimer's disease, as well as improved learning and memory.

引用

页码：664 / 668

页数：5

共 32 条

[1] Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice [J].