Growth and Shrinkage of Pluronic Micelles by Uptake and Release of Flurbiprofen: Variation of pH

被引：37

作者：

Alexander, Shirin ^{[1
]}

de Vos, Wiebe M. ^{[1
]}

Castle, Thomas C. ^{[2
]}

Cosgrove, Terence ^{[1
]}

Prescott, Stuart W. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Revolymer Ltd, Deeside CH5 2NT, Flint, Wales

来源：

LANGMUIR | 2012年 / 28卷 / 16期

基金：

英国工程与自然科学研究理事会;

关键词：

NONSTEROIDAL ANTIINFLAMMATORY DRUGS; BLOCK-COPOLYMER MICELLES; ANGLE NEUTRON-SCATTERING; AQUEOUS-SOLUTIONS; DISSOCIATION-CONSTANTS; POLY(ETHYLENE OXIDE); TRIBLOCK COPOLYMERS; WATER; MICELLIZATION; SOLUBILIZATION;

D O I：

10.1021/la204262w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The rnicellization of Pluronic triblock copolymers (P103, P123, and L43) in the presence of flurbiprofen at different pH was studied by small-angle neutron scattering (SANS), pulsed-field gradient stimulated-echo nuclear magnetic resonance (PFGSE-NMR), and surface tension measurements. Addition of flurbiprofen to the Pluronic at low pH leads to an increase in the fraction of micellization, aggregation number, and the core radius of the micelles. However, changing the pH to above the pK(a) of flurbiprofen in an ethanol/water mixture (similar to 6.5) reduces the fraction of micellization and results in a weaker interaction between the drug and micelles due to the increased drug solubility in aqueous solution.

引用

页码：6539 / 6545

页数：7

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