Coupled phase-variable expression and epitope masking of selective surface lipoproteins increase surface phenotypic diversity in Mycoplasma hominis

被引：19

作者：

Zhang, QJ ^{[1
]}

Wise, KS ^{[1
]}

机构：

[1] Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65212 USA

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 08期

关键词：

D O I：

10.1128/IAI.69.8.5177-5181.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A new mechanism expanding mycoplasmal surface diversity is described. Exposure of surface epitopes on a constitutively expressed membrane protein (P56) of Mycoplasma hominis was subject to high-frequency phase variation due to phase-variable expression of the P120 antigen and its selective masking of P56 epitopes. Phase-variable masking may confer previously unrealized adaptive capabilities on mycoplasmas.

引用

页码：5177 / 5181

页数：5

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