Circulating factors that influence the central nervous system remyelination

被引：7

作者：

Saitoh, Steve S. ^{[1
,2
]}

Tanabe, Shogo ^{[1
]}

Muramatsu, Rieko ^{[1
]}

机构：

[1] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mol Pharmacol, Tokyo 1878502, Japan

[2] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept NCNP Brain Physiol & Pathol, Tokyo 1138510, Japan

来源：

CURRENT OPINION IN PHARMACOLOGY | 2022年 / 62卷

关键词：

OLIGODENDROCYTE PROGENITOR CELLS; GROWTH-FACTOR; 21; BETA-KLOTHO; RECEPTOR; MYELIN; REGENERATION; BRAIN; FGF21; CNS; DIFFERENTIATION;

D O I：

10.1016/j.coph.2021.12.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Injury in the central nervous system leads to neurological deficits, depending on the disruption of neural networks. Remyelination, which occurs partially and spontaneously, is a critical process in the regeneration of neural networks to recover from neurological deficits. Remyelination depends on the development of oligodendrocytes, including the proliferation of oligodendrocyte precursor cells (OPCs) and the differentiation of OPCs into mature oligodendrocytes to form myelin. OPC proliferation and differentiation are regulated by intracellular and extracellular mechanisms, and recent studies have demonstrated that circulating factors secreted from peripheral organs or infiltrated immune cells play a key role in controlling oligodendrocyte development following remyelination in adult mammals. In this review, we describe the beneficial and detrimental effects of systemic environments, such as circulating factors derived from peripheral organs and immune cells, on CNS remyelination.

引用

页码：130 / 136

页数：7

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