Effects of supplementation with curcuminoids on serum adipokines in critically ill patients: a randomized double-blind placebo-controlled trial

被引：13

作者：

Shadnoush, Mahdi ^{[1
,2
]}

Zahedi, Hoda ^{[3
]}

Norouzy, Abdolreza ^{[4
]}

Sahebkar, Amirhossein ^{[5
,6
,7
]}

Sadeghi, Omid ^{[8
]}

Najafi, Atabak ^{[9
]}

Hosseini, Saeed ^{[3
]}

Qorbani, Mostafa ^{[10
]}

Ahmadi, Arezoo ^{[9
]}

Ardehali, Seyed Hossein ^{[11
]}

Hosseinzadeh-Attar, Mohammad Javad ^{[3
]}

机构：

[1] Semnan Univ Med Sci, Fac Med, Semnan, Iran

[2] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Dept Clin Nutr, Tehran, Iran

[3] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran

[4] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran

[5] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran

[6] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran

[7] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran

[8] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran

[9] Univ Tehran Med Sci, Sina Hosp, Fac Med, Dept Anesthesiol & Crit Care Med, Tehran, Iran

[10] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran

[11] Shahid Beheshti Univ Med Sci, Shohadaye Tajrish Hosp, Dept Anesthesiol & Crit Care, Tehran, Iran

来源：

PHYTOTHERAPY RESEARCH | 2020年 / 34卷 / 12期

关键词：

adiponectin; curcumin; enteral nutrition; intensive care unit; leptin; MAJOR DEPRESSION; GENE-EXPRESSION; ADIPONECTIN; LEPTIN; INFLAMMATION; EXTRACT; OBESITY; ROLES; IL-6;

D O I：

10.1002/ptr.6749

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Previous studies have shown a beneficial effect of curcuminoids supplementation on serum concentrations of adipokines; however, there are no published studies that have examined this effect among critically ill patients. We aimed to assess the effects of supplementation with curcuminoids on serum concentrations of leptin and adiponectin in critically ill patients with traumatic brain injury (TBI). In this trial, 62 critically ill patients with TBI, aged 18-65 years, were randomly allocated to receive either 500 mg/day curcuminoids (co-administered with 5 mg/day piperine) or matched placebo for 7 days. Patients in both intervention groups received routine treatments for TBI as well as enteral nutrition. Serum concentrations of leptin and adiponectin were measured at baseline and at the end of trial. We found a significant reduction in serum levels of leptin in both curcuminoids (47.1%) and placebo (22.8%) groups; though the magnitude of reduction was greater in the former (p < .05). Supplementation with curcumioinds was not found to alter serum concentrations of adiponectin (p > .05). Supplementation with curcumioinds significantly reduced serum levels of leptin but had no significant effect on adiponectin levels in critically ill patients with TBI. Further clinical trials, particularly those with a long-term period, are needed to confirm our findings.

引用

页码：3180 / 3188

页数：9

共 54 条

[1] Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals [J].