Synthesis of novel analogues of (+)-varitriol via olefin cross-metathesis reaction

被引：40

作者：

Nagarapu, Lingaiah ^{[1
]}

Paparaju, Venkateswarlu ^{[1
]}

Satyender, Apuri ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 2, Hyderabad 500607, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 07期

关键词：

varitriol; analogues; cross-metathesis reaction; Grubb's catalyst; cytotoxicity;

D O I：

10.1016/j.bmcl.2008.02.062

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel analogues of (+)-varitriol have been synthesized via olefin cross-metathesis reaction using Grubb's catalyst. Newly synthesized compounds were screened for cytotoxicity and they showed mild activity against RAW264.7 and HT29 cell lines. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2351 / 2354

页数：4

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