Dendron-mediated self-assembly of highly PEGylated block copolymers: a modular nanocarrier platform

被引：45
|
作者：
Bae, Jin Woo [2 ]
Pearson, Ryan M. [2 ]
Patra, Niladri [1 ]
Sunoqrot, Suhair [2 ]
Vukovic, Lela [1 ]
Kral, Petr [1 ]
Hong, Seungpyo [2 ]
机构：
[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA
[2] Univ Illinois, Dept Biopharmaceut Sci, Chicago, IL 60612 USA
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 37期
基金：
美国国家科学基金会;
关键词：
DRUG-DELIVERY; AQUEOUS-SOLUTIONS; POLY(ETHYLENE GLYCOL); MICELLES; NANOPARTICLES; AMPHIPHILES; RELEASE;
D O I：
10.1039/c1cc14331j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
PEGylated dendron coils (PDCs) were investigated as a novel potential nanocarrier platform. PDCs self-assembled into micelles at lower CMCs than linear copolymer counterparts by 1-2 orders of magnitude, due to the unique architecture of dendrons. MD simulations also supported thermodynamically favourable self-assembly mediated by dendrons.
引用
收藏
页码：10302 / 10304
页数：3
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