Bioinspired Concentric-Cylindrical Multilayered Scaffolds with Controllable Architectures: Facile Preparation and Biological Applications

被引：19

作者：

Cheng, Xiaopeng ^{[1
]}

Shi, Honghui ^{[1
]}

Wang, Zhaofei ^{[1
]}

Zheng, Guoqiang ^{[1
]}

Liu, Pingping ^{[1
]}

Dai, Kun ^{[1
]}

Liu, Chuntai ^{[1
]}

Shen, Changyu ^{[1
]}

机构：

[1] Zhengzhou Univ, Natl Engn Res Ctr Adv Polymer Proc Technol, Affiliated Hosp 1, Coll Mat Sci & Engn,Dept Immunol, Zhengzhou 450002, Henan, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2018年 / 10卷 / 50期

基金：

中国国家自然科学基金;

关键词：

multilayered scaffolds; controllable architectures; large scale; drug delivery; cell self-seeding; LOW-PRESSURE SYSTEM; HIERARCHICAL STRUCTURE; SEEDING EFFICIENCY; BONE-FORMATION; POLYMER; CELLS; COMBINATION; PERFUSION; CHITOSAN; SURFACE;

D O I：

10.1021/acsami.8b18095

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Multilayered objects are the most important and interesting structures in nature, exhibiting multiple functionalities. Inspired by the excellent structural-functional characteristics of nature creatures, concentric-cylindrical multilayered scaffolds were prepared by a combination of melt extrusion and leaching, in which well-defined alternating microlayer/gap is assembled. Furthermore, the macroscopic shape, internal structure, and surface topography of such a multilayered scaffold can be elaborately prepared by a simple physical process. The whole process has low cost, is efficient, and is environmentally friendly. Furthermore, such multilayered scaffolds show some interesting applications, e.g., lipophilic/hydrophilic drugs delivery and cell self-seeding. Considering the facile preparation process and versatile applications, this study will open up a new pathway to fabricate scaffolds with controllable architectures and expand their biodegradable polymer applications.

引用

页码：43512 / 43522

页数：11

共 48 条

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