Deubiquitinating enzymes in cancer stem cells: functions and targeted inhibition for cancer therapy

被引：39

作者：

Kaushal, Kamini ^{[1
]}

Antao, Ainsley Mike ^{[1
]}

Kim, Kye-Seong ^{[1
,2
]}

Ramakrishna, Suresh ^{[1
,2
]}

机构：

[1] Hanyang Univ, Grad Sch Biomed Sci & Engn, Seoul, South Korea

[2] Hanyang Univ, Coll Med, Seoul, South Korea

来源：

DRUG DISCOVERY TODAY | 2018年 / 23卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; POOR-PROGNOSIS; GROWTH-FACTOR; UP-REGULATION; IN-VIVO; UBIQUITIN; APOPTOSIS; EXPRESSION; PATHWAY;

D O I：

10.1016/j.drudis.2018.05.035

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The ability of cancers to evade conventional treatments, such as chemotherapy and radiation therapy, has been attributed to a subpopulation of cancer stem cells (CSCs). CSCs are regulated by mechanisms similar to those that regulate normal stem cells (NSCs), including processes involving ubiquitination and deubiquitination enzymes (DUBs) that regulate the expression of various factors, such as Notch, Wnt, Sonic Hedgehog (Shh), and Hippo. In this review, we discuss the roles of various DUBs involved in the regulation of core stem cell transcription factors and CSC-related proteins that are implicated in the modulation of cellular processes and carcinogenesis. In addition, we discuss the various DUB inhibitors that have been designed to target processes relevant to cancer and CSC maintenance.

引用

页码：1974 / 1982

页数：9

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