Polymer mimics of biomacromolecular antifreezes

被引：214

作者：

Biggs, Caroline I. ^{[1
]}

Bailey, Trisha L. ^{[1
]}

Graham, Ben ^{[1
]}

Stubbs, Christopher ^{[1
]}

Fayter, Alice ^{[1
]}

Gibson, Matthew I. ^{[1
,2
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

基金：

英国工程与自然科学研究理事会;

关键词：

ICE RECRYSTALLIZATION INHIBITION; POLY(VINYL ALCOHOL); CRYOPROTECTIVE PROPERTIES; FREE CRYOPRESERVATION; CRYSTAL-GROWTH; CELL-SURVIVAL; GLYCOPROTEINS; PROTEIN; ADSORPTION; NUCLEATION;

D O I：

10.1038/s41467-017-01421-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antifreeze proteins from polar fish species are remarkable biomacromolecules which prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue cryopreservation for transplantation, transfusion and basic biomedical research, as well as technological applications such as icing of aircraft wings. This review will introduce the rapidly emerging field of synthetic macromolecular (polymer) mimics of antifreeze proteins. Particular focus is placed on designing polymers which have no structural similarities to antifreeze proteins but reproduce the same macroscopic properties, potentially by different molecular-level mechanisms. The application of these polymers to the cryopreservation of donor cells is also introduced.

引用

页数：12

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