Bone marrow stromal cells (bone marrow-derived multipotent mesenchymal stromal cells) for bone tissue engineering: Basic science to clinical translation

被引：59

作者：

Kagami, Hideaki ^{[1
]}

Agata, Hideki ^{[1
]}

Tojo, Arinobu ^{[1
]}

机构：

[1] Univ Tokyo, Tissue Engn Res Grp, Div Mol Therapy, Adv Clin Res Ctr,Inst Med Sci,Minato Ku, Tokyo 1088639, Japan

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2011年 / 43卷 / 03期

关键词：

Bone marrow stromal cells; Multipotent mesenchymal stromal cells; Mesenchymal stem cells; MSCs; CFUs-F; Bone tissue engineering; STEM-CELLS; INTERNATIONAL-SOCIETY; THERAPY; DIFFERENTIATION; CULTURES;

D O I：

10.1016/j.biocel.2010.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone tissue engineering is a promising field of regenerative medicine in which cultured cells, scaffolds, and osteogenic inductive signals are used to regenerate bone. This technology has already been used in several clinical studies and its efficacy has been reported. In this review, we focus on bone marrow stromal cells, which are the most commonly used cell source for bone tissue engineering. The nature of the cells, suitable culture conditions for bone tissue engineering, and their potential therapeutic applications are reviewed with possible caveats. Furthermore, recent advances in bone marrow stromal cell biology are discussed with reference to clinical translation. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：286 / 289

页数：4

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