Involvement of progenitor cells in vascular repair

被引：40
作者：
Hibbert, B [1 ]
Olsen, S [1 ]
O'Brien, E [1 ]
机构：
[1] Univ Ottawa, Inst Heart, Div Cardiol, Vasc Biol Lab, Ottawa, ON K1Y 4W7, Canada
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2003年 / 13卷 / 08期
关键词：
D O I：
10.1016/j.tcm.2003.09.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Whereas the genesis of an arterial lesion is thought to be the result of migration and proliferation of vascular cells, recent insights into the biology of progenitor cells now question this concept. Specifically, endothelial and smooth muscle cells appear to be derived from multiple sources such as circulating stem and progenitor cells, as well as tissue-resident progenitor cell populations. These cells may engraft at sites of vascular injury and play an integral role in vascular repair. In this review, experimental data from in vitro studies, animal models, and scattered human observations are reviewed in the context of emerging hypotheses regarding the response to vascular injury.
引用
收藏
页码：322 / 326
页数：5
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