Improved cognitive function as a consequence of hepatitis C virus treatment

被引：44
作者：
Thein, H. H.
Maruff, P.
Krahn, M. D.
Kaldor, J. M.
Koorey, D. J.
Brew, B. J.
Dore, Gregory J.
机构：
[1] Univ New S Wales, Natl Ctr HIV Epidemiol & Clin Res, Sydney, NSW 2010, Australia
[2] La Trobe Univ, Sch Psychol, Melbourne, Vic, Australia
[3] CogState Ltd, Melbourne, Vic, Australia
[4] Univ Toronto, Dept Med, Management & Evaluat & Fac Pharm, Toronto, ON, Canada
[5] Univ Toronto, Dept Hlth Policy, Management & Evaluat & Fac Pharm, Toronto, ON, Canada
[6] Royal Prince Alfred Hosp, Gastroenterol & Hepatol Unit, Sydney, NSW, Australia
[7] St Vincents Hosp, Dept Neurol, Sydney, NSW 2010, Australia
[8] St Vincents Hosp, HIV Immunol Infect Dis Clin Serv Unit, Sydney, NSW 2010, Australia
来源：
HIV MEDICINE | 2007年 / 8卷 / 08期
关键词：
antiviral therapy; hepatitis C; HIV/HCV coinfection; neuropsychological effects; quality of life;
D O I：
10.1111/j.1468-1293.2007.00505.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Objective The aim of the study was to investigate the impact of treatment-related clearance of hepatitis C virus (HCV) on cognitive function. Methods A prospective study was conducted in 19 HCV-monoinfected and 15 HIV/HCV-coinfected individuals undergoing pegylated interferon alpha-2a and ribavirin therapy between April 2003 and August 2005. Neuropsychological, mood, and health-related quality of life (HRQOL) effects were assessed using computer-based battery, Trail Making Tests, Depression Anxiety Stress Scales and the Short Form-36 health survey. Results Pretreatment cognitive function, mood status, and HRQOL were similar between the HCV patient groups. Sustained virological response (SVR) rates were similar between HCV-monoinfected (68%) and HIV/HCV-coinfected (73%) groups. SVR was associated with significant improvements in some measures of cognitive function, independent of HRQOL improvement. Conclusions Our findings provide evidence to support cognitive effects of HCV independent of mood status and HRQOL profiles.
引用
收藏
页码：520 / 528
页数：9
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