Targeted Isolation of a Cytotoxic Cyclic Hexadepsipeptide from the Mesophotic Zone Sponge-Associated Fungus Cymostachys sp. NBUF082

被引：6

作者：

Yuan, Ye ^{[1
,2
]}

Li, Te ^{[1
,2
]}

Wang, Tingting ^{[1
]}

Naman, C. Benjamin ^{[1
]}

Ye, Jing ^{[3
]}

Wu, Xingxin ^{[3
]}

Lazaro, J. Enrico H. ^{[4
]}

Yan, Xiaojun ^{[2
]}

He, Shan ^{[1
]}

机构：

[1] Ningbo Univ, Dept Marine Pharm, Li Dak Sum Marine Biopharmaceut Res Ctr, Coll Food & Pharmaceut Sci, Ningbo 315832, Peoples R China

[2] Ningbo Univ, Sch Marine Sci, Ningbo 315832, Peoples R China

[3] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China

[4] Univ Philippines Diliman, Natl Inst Mol Biol & Biotechnol, Quezon City 1101, Philippines

来源：

MARINE DRUGS | 2021年 / 19卷 / 10期

基金：

中国国家自然科学基金;

关键词：

mesophotic zone; sponges; sponge-associated fungi; hexadepsipeptide; cytotoxicity; DEPSIPEPTIDE; METABOLITES; DERIVATIVES;

D O I：

10.3390/md19100565

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

LC-MS/MS-based molecular networking facilitated the targeted isolation of a new cyclic hexadepsipeptide, cymodepsipeptide (1), and two known analogues, RF-2691A (2) and RF-2691B (3), from the fungus Cymostachys sp. NBUF082 that was derived from a mesophotic zone Aaptos sponge collected near Apo Island. The constitution and configuration of 1 was elucidated through 1D and 2D NMR-spectroscopy, high resolution mass-spectrometry, and chemical degradations including Marfey's analysis and chiral HPLC. It was observed that 1 was moderately cytotoxic against CCRF-CEM human acute lymphocytic leukemia cells in vitro with the IC50 value of 9.2 & PLUSMN; 1.1 mu M.</p>

引用

页数：8

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