Multidirectional interplay between nuclear receptors and microRNAs

被引：21

作者：

Pandey, Deo Prakash ^{[1
]}

Picard, Didier ^{[1
]}

机构：

[1] Univ Geneva, Dept Biol Cellulaire, CH-1211 Geneva 4, Switzerland

来源：

CURRENT OPINION IN PHARMACOLOGY | 2010年 / 10卷 / 06期

基金：

瑞士国家科学基金会;

关键词：

BREAST-CANCER CELLS; MESSENGER-RIBONUCLEIC-ACID; ALPHA ER-ALPHA; ESTROGEN-RECEPTOR; GENE-EXPRESSION; POSTTRANSCRIPTIONAL REGULATION; TAMOXIFEN RESISTANCE; RNA; PROLIFERATION; TARGETS;

D O I：

10.1016/j.coph.2010.08.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nuclear receptors (NRs) form one of the largest superfamilies of transcription factors in metazoans MicroRNAs (miRNAs) are small non-coding RNAs that bind the 3' untranslated region (3'UTR) of target mRNAs to reduce their stability and/or translation miRNAs can directly regulate the protein output of target NR mRNAs, and, conversely the expression of miRNAs can be modulated by NRs at the transcriptional level At least one NR also regulates the posttranscriptional maturation of miRNAs by interacting with miRNA processing factors via NR co-regulators Moreover, miRNAs regulate NR signaling by targeting the mRNAs of NR co-regulators and target genes This complex set of interactions also leads to an extensive network of feedback and feedforward regulatory loops

引用

收藏

页码：637 / 642

页数：6

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