Asymmetric organocatalytic domino reactions of γ-nitroketones and enals

被引：74

作者：

Enders, Dieter ^{[1
]}

Narine, Arun A. ^{[1
]}

Benninghaus, Thomas R. ^{[1
]}

Raabe, Gerhard ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

SYNLETT | 2007年 / 11期

关键词：

Michael additions; aldol reactions; asymmetric synthesis; domino reactions; organocatalysis;

D O I：

10.1055/s-2007-984517

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral Substituted cyclohexene carbaldehydes are readily synthesized in excellent enantiomeric excesses from simple nitroketone and enal precursors. The domino Michael addition-aldol condensation reaction catalyzed by a chiral secondary amine involves tandem iminium-enamine activation.

引用

页码：1667 / 1670

页数：4

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