Asymmetric organocatalytic domino reactions of γ-nitroketones and enals

被引：74
作者：
Enders, Dieter [1 ]
Narine, Arun A. [1 ]
Benninghaus, Thomas R. [1 ]
Raabe, Gerhard [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
来源：
SYNLETT | 2007年 / 11期
关键词：
Michael additions; aldol reactions; asymmetric synthesis; domino reactions; organocatalysis;
D O I：
10.1055/s-2007-984517
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chiral Substituted cyclohexene carbaldehydes are readily synthesized in excellent enantiomeric excesses from simple nitroketone and enal precursors. The domino Michael addition-aldol condensation reaction catalyzed by a chiral secondary amine involves tandem iminium-enamine activation.
引用
收藏
页码：1667 / 1670
页数：4
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