Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo

被引:41
作者
Yang, Gang-Gang [1 ]
Zhang, Hang [1 ]
Zhang, Dong-Yang [1 ]
Cao, Qian [1 ]
Yang, Jing [1 ]
Ji, Liang-Nian [1 ]
Mao, Zong-Wan [1 ]
机构
[1] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Cancer-specific chemotherapy; ROS regenerative feedback; Visualized drug release; Vitamin K3; Ruthenium complex; PHOTODYNAMIC THERAPY; NANOPARTICLES; DELIVERY; OXIDOREDUCTASE; CYTOTOXICITY; INFLAMMATION; EXPRESSION; OXIDATION; CELLS;
D O I
10.1016/j.biomaterials.2018.08.065
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A promising theranostic nanosystem VK3-CPT@Ru-CD is designed and fabricated by the host-guest driven self assembly between the fluorescent adamantine-functionalized Ru(II) complexes and the ROS-labile-cyclodextrin modified thioketal linkers, in which anticancer drug camptothecin (CPT) and vitamin K3 (VK3) are effectively co-encapsulated. On account of the generative feedback between the intracellular redox cycling of VK3 and the high degree of ROS-triggered collapse of nanoparticles, VK3-CPT@Ru-CD can facilitate cancer-specific ROS amplification and drug release selectively in cancer cells, thus realizing the selective killing of tumor with minimal side-effects both in vitro and in vivo, the therapeutic effect of which is more prominent than the free anticancer drugs. More interestingly, the menadione structure of encapsulated VK3 can effectively quench the inherent fluorescence of Ru-CD, and a fluorescence lightening up phenomenon is observed accompanied with the ROS-triggered drug release, which can be utilized for real-time tracking of drug release in vitro and in vivo.
引用
收藏
页码:73 / 85
页数:13
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