Drug monitoring of lamotrigine and oxcarbazepine combination during pregnancy

被引：32
作者：
Wegner, Ilse [1 ]
Edelbroek, Peter [1 ]
de Haan, Gerrit-Jan [1 ]
Lindhout, Dick [1 ,2 ]
Sander, Josemir W. [1 ,3 ]
机构：
[1] SEIN, Epilepsy Inst Netherlands, NL-8025 BV Zwolle, Netherlands
[2] Univ Med Ctr Utrecht, DBG Dept Med Genet, Utrecht, Netherlands
[3] UCL Inst Neurol, Dept Clin & Expt Epilepsy, London, England
来源：
EPILEPSIA | 2010年 / 51卷 / 12期
关键词：
Epilepsy; Pregnancy; Lamotrigine; Oxcarbazepine; Pharmacokinetics; ANTIEPILEPTIC DRUGS; PHARMACOKINETICS; WOMEN;
D O I：
10.1111/j.1528-1167.2010.02771.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
P>Little is known about pregnancy-induced alterations in the pharmacokinetics of the newer antiepileptic drugs, especially when used in combinations. Two women receiving combination therapy of lamotrigine (LTG) and oxcarbazepine (OXC) were followed prospectively during pregnancy and puerperium. Steady-state concentrations of LTG and the active metabolite of OXC, 10-hydroxycarbazepine (MHD), were measured at regular intervals using a dried blood spot method, and clearances were calculated. A strong effect of pregnancy on the clearance of both LTG and MHD was seen. An increase in seizure frequency occurred in both women. This stresses the importance of therapeutic drug monitoring of LTG and MHD during pregnancy. In case of breakthrough seizures or increased seizure frequency, dosage adjustment of both drugs may be required.
引用
收藏
页码：2500 / 2502
页数：3
相关论文
共 13 条
  • [1] Oxcarbazepine concentrations during pregnancy: A retrospective study in patients with epilepsy
    Christensen, Jakob
    Sabers, Anne
    Sidenius, Per
    [J]. NEUROLOGY, 2006, 67 (08) : 1497 - 1499
  • [2] Gestation-induced changes in lamotrigine pharmacokinetics:: A monotherapy study
    de Haan, GJ
    Edelbroek, P
    Segers, J
    Engelsman, M
    Lindhout, D
    Dévilé-Notschaele, M
    Augustijn, P
    [J]. NEUROLOGY, 2004, 63 (03) : 571 - 573
  • [3] Kramer Gunter, 2003, Epilepsia, V44, P95
  • [4] Landmark CJ, 2010, EXPERT REV NEUROTHER, V10, P119, DOI [10.1586/ERN.09.136, 10.1586/ern.09.136]
  • [5] Changes in the disposition of oxcarbazepine and its metabolites during pregnancy and the puerperium
    Mazzucchelli, I
    Onat, FY
    Ozkara, C
    Atakli, D
    Specchio, LM
    Neve, AL
    Gatti, G
    Perucca, E
    [J]. EPILEPSIA, 2006, 47 (03) : 504 - 509
  • [6] Plasma concentrations of lamotrigine and its 2-N-glucuronide metabolite during pregnancy in women with epilepsy
    Ohman, Inger
    Beck, Olof
    Vitols, Sigurd
    Tomson, Torbjorn
    [J]. EPILEPSIA, 2008, 49 (06) : 1075 - 1080
  • [7] Lamotrigine in pregnancy: Clearance, therapeutic drug monitoring, and seizure frequency
    Pennell, P. B.
    Peng, L.
    Newport, D. J.
    Ritchie, J. C.
    Koganti, A.
    Holley, D. K.
    Newman, M.
    Stowe, Z. N.
    [J]. NEUROLOGY, 2008, 70 (22) : 2130 - 2136
  • [8] The impact of pregnancy and childbirth on the metabolism of lamotrigine
    Pennell, PB
    Newport, DJ
    Stowe, ZN
    Helmers, SL
    Montgomery, JQ
    Henry, TR
    [J]. NEUROLOGY, 2004, 62 (02) : 292 - 295
  • [9] Seizure deterioration in women treated with oxcarbazepine during pregnancy
    Petrenaite, Vaiva
    Sabers, Anne
    Hansen-Schwartz, Jacob
    [J]. EPILEPSY RESEARCH, 2009, 84 (2-3) : 245 - 249
  • [10] In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction
    Rowland, Andrew
    Elliot, David J.
    Williams, J. Andrew
    MacKenzie, Peter I.
    Dickinson, Ronald G.
    Miners, John O.
    [J]. DRUG METABOLISM AND DISPOSITION, 2006, 34 (06) : 1055 - 1062
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