Chemical constituents from the stems of Acanthopanax senticosus with their cytotoxic activities

被引：3

作者：

Chen, Xian-Hua ^{[1
]}

Zhao, Yu-Ying ^{[2
]}

Wang, Qi ^{[2
]}

Li, Zhi-Ling ^{[1
]}

Li, Feng-Xia ^{[1
]}

Tan, Hong-Yu ^{[2
]}

Huang, Yue-Yue ^{[2
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Tradit Chinese Med, Shenzhen 518107, Peoples R China

[2] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou 510006, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2022年 / 24卷 / 07期

关键词：

Acanthopanax senticosus; Araliaceae; coumestan; cytotoxic activity;

D O I：

10.1080/10286020.2021.1951713

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new coumestan named 7,5'-dihydroxy-4'-(3''-hydroxy-3''-methyl-trans-isobut-1''-enyl) coumestan (1), together with five known compounds (2-6), was isolated from the EtOAc-soluble extract of the stems of Acanthopanax senticosus. Their structures were elucidated based on extensive spectroscopic analyses. All the isolates were evaluated for in vitro cytotoxic activities against four human cancer cells including HepG2, A549, HeLa and MCF-7. Among them, the new compound 1 was found to exhibit significant cytotoxic activity on HeLa cells with IC50 value of 6.5 mu M.

引用

页码：673 / 678

页数：6

共 17 条

[1] A new bioactive coumestan from the seeds of Psoralea corylifolia
Chai, Ming-Yan
[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2020, 22 (03) : 295 - 301
[2] Lupane Glycosides from the Leaves of Acanthopanax koreanum
Choi, Hyun-Sik
Kim, Hyoung Ja
Nam, Sang-Gil
Kim, In-Seon
Lee, Kyung-Tae
Yook, Chang-Soo
Lee, Yong Sup
[J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (11) : 1613 - 1616
[3] Spongian-16-one Diterpenes and Their Anatomical Distribution in the Australian Nudibranch Goniobranchus collingwoodi
Forster, Louise C.
Winters, Anne E.
Cheney, Karen L.
Dewapriya, Pradeep
Capon, Robert J.
Garson, Mary J.
[J]. JOURNAL OF NATURAL PRODUCTS, 2017, 80 (03): : 670 - 675
[4] HASHIMOTO Y, 1994, MOKUZAI GAKKAISHI, V40, P549
[5] Biologically active triterpenoid saponins from Acanthopanax senticosus
Jiang, Wenhong
Li, Wei
Han, Likun
Liu, Lijuan
Zhang, Qingbo
Zhang, Shujie
Nikaido, Tamotsu
Koike, Kazuo
[J]. JOURNAL OF NATURAL PRODUCTS, 2006, 69 (11): : 1577 - 1581
[6] Acanthopanax senticosus has a heme oxygenase-1 signaling-dependent effect on Porphyromonas gingivalis lipopolysaccharide-stimulated macrophages
Kim, Hye Soo
Park, Sun Young
Kim, Eun Kyoung
Ryu, Eun Yeon
Kim, Young Hun
Park, Geuntae
Lee, Sang Joon
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2012, 142 (03) : 819 - 828
[7] A review on the immunomodulatory activity of Acanthopanax senticosus and its active components
Lau, Kit-Man
Yue, Grace Gar-Lee
Chan, Yuk-Yu
Kwok, Hin-Fai
Gao, Si
Wong, Chun-Wai
Lau, Clara Bik-San
[J]. CHINESE MEDICINE, 2019, 14 (1)
[8] New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity
Li, Jia-Lin
Li, Na
Xing, Shan-Shan
Zhang, Nan
Li, Ban-Ban
Chen, Jian-Guang
Ahn, Jong-Seog
Cui, Long
[J]. ARCHIVES OF PHARMACAL RESEARCH, 2017, 40 (11) : 1265 - 1270
[9] Acanthopanax senticosus: Photochemistry and Anticancer Potential
Li, Ting
Ferns, Kelsey
Yan, Zi-Qiao
Yin, Si-Yuan
Kou, Jun-Jie
Li, Dongsheng
Zeng, Zheng
Yin, Lin
Wang, Xiaoyu
Bao, Hong-Xia
Zhou, Yu-Jie
Li, Qing-Hai
Zhao, Zhan-Yi
Liu, Huidi
Liu, Shu-Lin
[J]. AMERICAN JOURNAL OF CHINESE MEDICINE, 2016, 44 (08): : 1543 - 1558
[10] Acanthopanax senticosus extracts have a protective effect on Drosophila gut immunity
Li, Wenjia
Luo, Qiuxiang
Jin, Li Hua
[J]. JOURNAL OF ETHNOPHARMACOLOGY, 2013, 146 (01) : 257 - 263

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