+mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain

被引：6
|
作者：
Zhang, Ying-Ying [1 ]
Han, Xue [1 ]
Liu, Ye [2 ,3 ]
Chen, Jian [1 ]
Hua, Lei [1 ]
Ma, Qian [1 ]
Huang, Yang-Yu-Xin [1 ]
Tang, Qiong-Yao [1 ,2 ,3 ]
Zhang, Zhe [1 ,2 ,3 ]
机构：
[1] Xuzhou Med Univ, Sch Anesthesiol, Xuzhou, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Jiangsu Prov Key Lab Anesthesiol, Xuzhou, Jiangsu, Peoples R China
[3] Xuzhou Med Univ, Jiangsu Prov Key Lab Anesthesia & Analgesia Appli, Xuzhou, Jiangsu, Peoples R China
来源：
PLOS ONE | 2018年 / 13卷 / 01期
关键词：
BK CHANNEL ACTIVATION; K+ CHANNEL; POTASSIUM CHANNELS; SLO3; SUBUNIT; CALCIUM; DEFICIENCY; EPILEPSY; DOMAIN; CELLS;
D O I：
10.1371/journal.pone.0191749
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
LRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary. subunit of BK (Big conductance potassium channel) channels, which leftward shifts GVs of BK channels around 50 mV in the absence of cytosolic Ca2+. LRRC55 protein is also the only. subunit of BK channels that is expressed in mammalian nervous system. However, the expression pattern of LRRC55 gene in adult mammalian brain remains elusive. In this study, we investigated the distribution of LRRC55 mRNA in the adult mouse brain by using in situ hybridization. We found that LRRC55 mRNA is richly expressed in the adult mouse medial habenula nucleus (MHb), cerebellum and pons. However, the potential role of LRRC55 in MHb and cerebellum could be different based on the function of BK channels in these brain regions.
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页数：10
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