Synthesis of Mycinose from 1,2:5,6-Di-O-Isopropylidene-α-D-glucofuranose

被引：1

作者：

Bao, Kai ^{[1
,2
]}

Gao, Hao ^{[2
]}

Zhu, Zhibin ^{[1
]}

Wang, Jinhong ^{[1
]}

Zhang, Guoning ^{[1
]}

Sun, Jun ^{[1
]}

Zhang, Weige ^{[1
]}

Yao, Xinsheng ^{[2
,3
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

来源：

LETTERS IN ORGANIC CHEMISTRY | 2011年 / 8卷 / 08期

基金：

美国国家科学基金会;

关键词：

1,2:5,6-Di-O-Isopropylidene-alpha-D-glucofuranose; debromination; mycinose; synthesis; DERIVATIVES; ANTIBIOTICS; CYCLIZATION; MACROLIDE; PRODUCT;

D O I：

10.2174/157017811797249290

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthesis of mycinose from commercially available 1,2: 5,6-Di-O-isopropylidene-alpha-D-glucofuranose was developed. A selective and direct reductive debromination of alpha-hydroxy bromides in a simple NaBH4/EtOH/H2O system was found.

引用

页码：592 / 595

页数：4

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