The role of rare earth elements in bone tissue engineering scaffolds-A review

被引:51
作者
Gao, Juanjuan [1 ]
Feng, Liang [1 ]
Chen, Baolong [1 ]
Fu, Biao [1 ]
Zhu, Min [1 ]
机构
[1] Univ Shanghai Sci & Technol, Sch Mat & Chem, Shanghai, Peoples R China
关键词
Rare earth elements; Bone tissue engineering; Porous metals; Bioceramics; Scaffolds; IN-VITRO BIOACTIVITY; SUBSTITUTED HYDROXYAPATITE NANOPARTICLES; CERIUM OXIDE; MAGNESIUM ALLOYS; DRUG-DELIVERY; OSTEOGENIC DIFFERENTIATION; MINERALIZATION FUNCTION; CORROSION-RESISTANCE; COMPOSITE COATINGS; GLASS SCAFFOLDS;
D O I
10.1016/j.compositesb.2022.109758
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Rare earth elements (REEs) have gained spotlights with particular features to promote bone regeneration. Therefore, the introduction of appropriate REEs into bone tissue engineering (BTE) scaffolds is nowadays a promising strategy in order to achieve optimized bone repair performances. In this review, direct uses of REE compound nanoadditives in BTE scaffolds are first of all reviewed to illustrate the fundamental effects of REE towards bone regeneration. Then the Re-containing biodegradable porous alloys and Re-doped bioceramic-based scaffolds are discussed, respectively. REEs play functional roles in those materials with physical, chemical and biological improvements. Moreover, REEs-related biological effects including osteogenic, angiogenic and anti-bacterial properties that facilitate bone regeneration are also reviewed. This study is aiming to invoke diverse and comprehensive studies to investigate and improve the utilization of REEs in bone tissue engineering.
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页数:15
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