pTis and pT1a Ipsilateral Breast Tumor Recurrence Is Associated with Good Prognosis after Salvage Surgery

被引：3

作者：

Ishitobi, Makoto ^{[1
]}

Fukui, Reiko ^{[1
]}

Hashimoto, Yoko ^{[1
]}

Kittaka, Nobuyoshi ^{[1
]}

Nakayama, Takahiro ^{[1
]}

Tamaki, Yasuhiro ^{[1
]}

机构：

[1] Osaka Int Canc Inst, Dept Breast & Endocrine Surg, Osaka, Japan

来源：

ONCOLOGY | 2018年 / 94卷 / 01期

关键词：

Breast cancer; Breast-conserving treatment; Ipsilateral breast tumor recurrence; Tumor size; Prognosis; CLINICAL-PRACTICE GUIDELINES; SURGICAL ADJUVANT BREAST; 20-YEAR FOLLOW-UP; LOCAL RECURRENCE; CONSERVATIVE SURGERY; CONSERVING SURGERY; CANCER RECURRENCE; LOCOREGIONAL RECURRENCES; RADIATION-THERAPY; RANDOMIZED-TRIAL;

D O I：

10.1159/000480516

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: Patients with ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery have a poor prognosis. There is little information regarding the prognostic impact of the tumor size in patients with IBTR. Methods: A total of 143 patients who had histologically confirmed IBTR without distant metastases and who underwent salvage surgery between 1989 and 2013 in our hospital were included. Distant disease-free survival (DDFS) was calculated according to the invasive tumor size of IBTR. The median follow-up period was 4.6 years. Results: Patients with pT1b or more advanced IBTR have a high (>= 20%) 5-year distant recurrence risk. There were significant differences in DDFS between patients with pTis or pT1a and those with pT1b or a more advanced stage (5-year DDFS: 94.4 vs. 70.1%, respectively, p value = 0.006). This significance remained after adjusting for other clinicopathological factors (p value = 0.04). Conclusion: Patients with pTis or pT1a IBTR have a good prognosis after salvage surgery for IBTR, and the omission of adjuvant chemotherapy could be considered. Further research and validation studies are needed. (C) 2017 S. Karger AG, Basel

引用

页码：12 / 18

页数：7

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